Raise Cain Meaning

(idiomatic) To behave in a disruptive manner.

Example:   If those boys have been out drinking and raising Cain again tonight...
1883, Robert Louis Stevenson, Treasure Island:
  "I seen old Flint in the corner there, behind you; as plain as print, I seen him; and if I get the horrors, I'm a man that has lived rough, and I'll raise Cain."