Set Up Shop Meaning

(idiomatic) To establish a business.

Example: To physically arrange a shop or workplace.
  He set up shop in his garage every Saturday.
  They set up shop as venture capitalists on Sand Hill Road.
2012 June 3, Nathan Rabin, “TV: Review: THE SIMPSONS (CLASSIC): “Mr. Plow” (season 4, episode 9; originally aired 11/19/1992)”[1]:
  Homer’s entrepreneurial spirit proves altogether overly infectious. Homer gives Barney a pep talk when he encounters him dressed up like a baby handing out fliers (Barney in humiliating costumes=always funny) and it isn’t long until Barney has purchased a truck of his own and set up shop as the Plow King.
2010 September, Derek Rapp, "Good Company", St. Louis magazine, ISSN 1090-5723, volume 16, issue 9, page 80:
  […] these companies could enjoy support required to set up shop for the long term.